R Chan, J Leung, J Woo
Nov 24, 2014
Journal: Nutrients
DOI: 10.3390/nu17121958
Association Between Estimated Net Endogenous Acid Production and Subsequent Decline in Muscle Mass Over Four Years in Ambulatory Older Chinese People in Hong Kong: A Prospective Cohort Study
Abstract
Background: Findings regarding dietary acid-base balance and muscle loss were mainly reported in Caucasian populations and seldom documented in Chinese population with different dietary habits. This prospective study examined such association in 3,122 Chinese community-dwelling older people aged 65 and over in Hong Kong.
Methods: Baseline dietary intakes were assessed using a validated food frequency questionnaire. Estimated net endogenous acid production (NEAP) was calculated using Frassetto's method based on the diet's protein to potassium ratio. Nutrient intakes and estimated NEAP were energy-adjusted by residual method. Estimated NEAP was divided into sex-specific energy-adjusted quartiles for data analysis. Four-year change in appendicular skeletal muscle mass (ASM) from baseline was assessed using dual-energy X-ray absorptiometry. Analysis of covariance was used to investigate the association between quartiles of estimated NEAP and 4-year change in ASM with adjustments for potential covariates.